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What makes Biblio different? Facebook Instagram Twitter. Sign In Register Help Cart. Cart items. In a typical MS procedure, a sample, which may be solid, liquid, or gas, is ionized, for example by bombarding it with electrons. These ions are then separated according to their mass-to-charge ratio, typically by accelerating them and subjecting them to an electric or magnetic field: ions of the same mass-to-charge ratio will undergo the same amount of deflection. The ions are detected by a mechanism capable of detecting charged particles, such as an electron multiplier.
Results are displayed as spectra of the relative abundance of detected ions as a function of the mass-to-charge ratio. The atoms or molecules in the sample can be identified by correlating known masses to the identified masses or through a characteristic fragmentation pattern.
Mass spectrometry has both qualitative and quantitative uses. These include identifying unknown compounds, determining the isotopic composition of elements in a molecule, and determining the structure of a compound by observing its fragmentation. Other uses include quantifying the amount of a compound in a sample or studying the fundamentals of gas phase ion chemistry the chemistry of ions and neutrals in a vacuum.
Mass Spectrometry: A Foundation Course
MS is now in very common use in analytical laboratories that study physical, chemical, or biological properties of a great variety of compounds. A few of the disadvantages of the method is that often fails to distinguish between optical and geometrical isomers and the positions of substituent in o-, m- and p- positions in an aromatic ring. Also, its scope is limited in identifying hydrocarbons that produce similar fragmented ions. Pharmacokinetics is often studied using mass spectrometry because of the complex nature of the matrix often blood v or urine and the need for high sensitivity to observe low dose and long time point data.
The most common instrumentation used in this application is LC-MS with a triple quadrupole mass spectrometer. Tandem mass spectrometry is usually employed for added specificity. Standard curves and internal standards are used for quantitation of usually a single pharmaceutical in the samples. The samples represent different time points as a pharmaceutical is administered and then metabolized or cleared from the body.
Much attention is paid to the linearity of the standard curve; however it is not uncommon to use curve fitting with more complex functions such as quadratics since the response of most mass spectrometers is less than linear across large concentration ranges. There is currently considerable interest in the use of very high sensitivity mass spectrometry for microdosing studies, which are seen as a promising alternative to animal experimentation.
Mass spectrometry is an important method for the characterization and sequencing of proteins. In keeping with the performance and mass range of available mass spectrometers, two approaches are used for characterizing proteins. In the first, intact proteins are ionized by either of the two techniques described above, and then introduced to a mass analyzer. The top-down approach however is largely limited to low-throughput single-protein studies.
In the second, proteins are enzymatically digested into smaller peptides using proteases such as trypsin or pepsin, either in solution or in gel after electrophoretic separation.
The Irish Mass Spectrometry Society
Other proteolytic agents are also used. The collection of peptide products are then introduced to the mass analyzer. Book Description Royal Society of Chemistry. Condition: New. New copy - Usually dispatched within 2 working days. Seller Inventory B More information about this seller Contact this seller. Language: English. Brand new Book.
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Mass Spectrometry: A Foundation Course is a textbook covering the field of mass spectrometry across the chemical, physical, biological, medical and environmental sciences. Sufficient depth is provided for the reader to appreciate the reasons behind and basis for particular experiments. It is uniquely and logically organised to enable the book to form the basis for a university course in mass spectrometry at the undergraduate or postgraduate level.
This is achieved by combining specific core sections coupled to optional areas of study tailored to students of the chemical, physical, biological, medical and environmental sciences. Recommended course structures are provided in the front of the book. Dedicated chapters are included on: organic mass spectrometry; ion chemistry - to emphasise the role of mass spectrometry in fundamental chemistry and physics; biological mass spectrometry including proteomics; mass spectrometry in medicine, environmental and surface science and accelerator mass spectrometry, to emphasise the importance of these areas.
Each chapter concludes with key references and additional recommended reading material, making the book an excellent springboard to further study. Highly readable, easy-to-use and logically presented, Mass Spectrometry: A Foundation Course is an ideal text for students and for those who work with mass spectrometers who wish to gain a solid understanding of the basics in modern mass spectrometry. Seller Inventory AAV Book Description RSC, New Book. Shipped from UK. Established seller since Seller Inventory CA Book Description Royal Society of Chemistry, Book Description Book Description Condition: New.
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