Peptides 10 : — Hirschmann, R. B The versatile steroid nucleus: Design and synthesis of a peptidomimetic employing this novel scaffold. Tetrahedron 49 : — III. Usman, N. Chemical modification of hammerhead ribozymes: activity and nuclease resistance. Nucleic Acids Symposium Series 31 : — Goodchild, J. Nucleic Acids Res. Lathaam, J.
Nucleic Acids Res 22 : — Pieken, W. B, Benseler, F. Olsen, D. Biochemistry 30 : — Heidenreich, O. Aurup, H. Nucleic Acids Res 22 : 20— Lenstra, J. Isolation of sequences from a random-sequence expression library mat mimic viral epitopes. Methods : — Christian, R. Simplified methods for construction, assessment and rapid screening of peptide libraries in bacteriophage. Dedman, J. Selection of targeted biological modifiers from a bacteriophage library of random peptides. The identification of novel calmodulin regulatory peptides. Barbas, C. Semisyn-thetk combinatorial antibody libraries: A chemical solution to the diversity problem.
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In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Collect, T. A, Roben, P. A A binary plasmid system for shuffling combinatorial antibody libraries.
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Munir, K. Thymidine kinase mutants obtained by random sequence selection. USA 90 : — Burton, D. Monoclonal antibodies from combinatorial libraries. Accounts Chem. Posner, B. Catalytic antibodies: perusing combinatorial libraries. TIBS 19 : — Selection of human anti-hapten antibodies from semisynthetic libraries.
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In silico and in vitro methods in modern drug discovery
Holzmayer, T. Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments. Acids Res. Dube, D. Selection of new biologically active molecules from random nucleotide sequences.
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Direct selection for a catalytic mechanism from combinatorial antibody libraries. Brossalina, E. A DNA hairpin as a target for antisense oligonucleotides. Mattheakis, L. An in vitro polysome display system for identifying ligands from very large peptide libraries. Noonberg, S. In vivo generation of highly abundant sequence-specific oligonucleotides for antisense and triplex gene regulation.
Deiss, L. A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal. Geysen, H. Screening chemically synthesized peptide libraries for biologically-relevant molecules. Erb, E. Recursive deconvolution of combinatorial chemical libraries. Houghten, R. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature : 84— Eichler, J. Identification of substrate-analog tryp-sin inhibitors through the screening of synthetic peptide combinatorial libraries.
The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides. Peptide Research 5 : — Ecker, D. Rational screening of oligonucleotide combinatorial libraries for drug discovery.
Strategies for Identifying Drug Targets
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Light-generated oligonucleotide arrays for rapid DNA sequence analysis. A study of oligonucleotide reassociation using large arrays of oligonucleotides synthesised on a glass support. Oligonucleotide hybridisations on glass supports: A novel linker for oligonucleotide synthesis and hybridisation properties of oligonucleotides synthesised in situ. Matson, R. Biopolymer synthesis on polypropylene supports: Oligonucleotide arrays.
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An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library. Lam, K. Discovery of D-amino-acid-containing ligands with selectide technology. Gene : 13— Hagihara, M. Vinylogous Polypeptides: An alternative peptide backbone. The focus of Dr. Robert Britton's Natural Product Research Program is the total synthesis of natural products that represent potential lead candidates for the treatment of human diseases. In particular, his group is focusing on developing novel synthetic pathways to manufacture sufficient quantities of eleutherobin and biselide A, two natural products that hold potential for the treatment of cancer, as well as a family of imminosugars that represent leads for the treatment of diabetes, viral diseases, and lyposomal storage disorders.
The work of his team involves the development of innovative synthetic reactions that will allow them to construct complex natural products in a straightforward manner from simple chemical building blocks. The synthesis of these molecules will also enable the discovery of new substances that are similar in structure to these natural products but with potentially improved pharmaceutical properties.
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