Drug Discovery Strategies and Methods


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Peptides 10 : — Hirschmann, R. B The versatile steroid nucleus: Design and synthesis of a peptidomimetic employing this novel scaffold. Tetrahedron 49 : — III. Usman, N. Chemical modification of hammerhead ribozymes: activity and nuclease resistance. Nucleic Acids Symposium Series 31 : — Goodchild, J. Nucleic Acids Res. Lathaam, J.

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Nucleic Acids Res 22 : — Pieken, W. B, Benseler, F. Olsen, D. Biochemistry 30 : — Heidenreich, O. Aurup, H. Nucleic Acids Res 22 : 20— Lenstra, J. Isolation of sequences from a random-sequence expression library mat mimic viral epitopes. Methods : — Christian, R. Simplified methods for construction, assessment and rapid screening of peptide libraries in bacteriophage. Dedman, J. Selection of targeted biological modifiers from a bacteriophage library of random peptides. The identification of novel calmodulin regulatory peptides. Barbas, C. Semisyn-thetk combinatorial antibody libraries: A chemical solution to the diversity problem.

Zebedee, S. R,, Lerner, R. Gram, H. A and Kang, A.

In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Collect, T. A, Roben, P. A A binary plasmid system for shuffling combinatorial antibody libraries.


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Munir, K. Thymidine kinase mutants obtained by random sequence selection. USA 90 : — Burton, D. Monoclonal antibodies from combinatorial libraries. Accounts Chem. Posner, B. Catalytic antibodies: perusing combinatorial libraries. TIBS 19 : — Selection of human anti-hapten antibodies from semisynthetic libraries.

Gene : 57— Eigen, M. The Hypercycle. Friedman, A. Expression of a truncated viral trans-activator selectively impedes lytic infection by its cognate virus.

In silico and in vitro methods in modern drug discovery

Holzmayer, T. Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments. Acids Res. Dube, D. Selection of new biologically active molecules from random nucleotide sequences.

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Gene : 41— Janda, K. L,, Li, T.

Direct selection for a catalytic mechanism from combinatorial antibody libraries. Brossalina, E. A DNA hairpin as a target for antisense oligonucleotides. Mattheakis, L. An in vitro polysome display system for identifying ligands from very large peptide libraries. Noonberg, S. In vivo generation of highly abundant sequence-specific oligonucleotides for antisense and triplex gene regulation.

Deiss, L. A genetic tool used to identify thioredoxin as a mediator of a growth inhibitory signal. Geysen, H. Screening chemically synthesized peptide libraries for biologically-relevant molecules. Erb, E. Recursive deconvolution of combinatorial chemical libraries. Houghten, R. Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature : 84— Eichler, J. Identification of substrate-analog tryp-sin inhibitors through the screening of synthetic peptide combinatorial libraries.

The use of synthetic peptide combinatorial libraries for the identification of bioactive peptides. Peptide Research 5 : — Ecker, D. Rational screening of oligonucleotide combinatorial libraries for drug discovery.

Strategies for Identifying Drug Targets

A priori delineation of a peptide which mimics a discontinuous antigenic determinant. Molecular Immunology 23 : — Salmon, S. Discovery of biologically active peptides in random libraries: Solution-phase testing after staged orthogonal release from resin beads. Lebl, M. Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage-cleavage chemistry. Protein Res. Fodor, S. Light-directed, spatially addressable parallel chemical synthesis. Scienc : — Maskos, U. Parallel analysis of oligodeoxynbonu-deotide oligonucleotide interactions.

Analysis of factors influencing oligonucleotide duplex formation. Pease, A. J, Cronin, M.

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Light-generated oligonucleotide arrays for rapid DNA sequence analysis. A study of oligonucleotide reassociation using large arrays of oligonucleotides synthesised on a glass support. Oligonucleotide hybridisations on glass supports: A novel linker for oligonucleotide synthesis and hybridisation properties of oligonucleotides synthesised in situ. Matson, R. Biopolymer synthesis on polypropylene supports: Oligonucleotide arrays.

Maeji, N. Simultaneous multiple synthesis of peptide-carrier conjugates. Cooley, C.


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An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library. Lam, K. Discovery of D-amino-acid-containing ligands with selectide technology. Gene : 13— Hagihara, M. Vinylogous Polypeptides: An alternative peptide backbone. The focus of Dr. Robert Britton's Natural Product Research Program is the total synthesis of natural products that represent potential lead candidates for the treatment of human diseases. In particular, his group is focusing on developing novel synthetic pathways to manufacture sufficient quantities of eleutherobin and biselide A, two natural products that hold potential for the treatment of cancer, as well as a family of imminosugars that represent leads for the treatment of diabetes, viral diseases, and lyposomal storage disorders.

The work of his team involves the development of innovative synthetic reactions that will allow them to construct complex natural products in a straightforward manner from simple chemical building blocks. The synthesis of these molecules will also enable the discovery of new substances that are similar in structure to these natural products but with potentially improved pharmaceutical properties.

All rights reserved. Terms of Use. Jump to Navigation. You will also be shown how to use computers, statistics and various computer packages and will be required to present posters and talks as part of the assessment programme for a number of modules on this course. You will also get the opportunity to engage with professionals and guest speakers. You will apply the knowledge gained throughout the course by systemically developing a business strategy and use your skills to pitch your business plan to potential investors and collaborators, amalgamating your expertise in sciences and business acumen.

If your first language is not English, you will need to meet the minimum requirements of an English Language qualification. Currently, our students can qualify for the CMI's Certificate in Strategic Management and Leadership in addition to their MSc award from the University of Huddersfield after successfully completing the course. This course you will enable you to learn the necessary skills needed to start-up new businesses offering specialised services in drug discovery or join drug discovery teams within the pharmaceutical industry.

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Drug Discovery Strategies and Methods Drug Discovery Strategies and Methods
Drug Discovery Strategies and Methods Drug Discovery Strategies and Methods
Drug Discovery Strategies and Methods Drug Discovery Strategies and Methods
Drug Discovery Strategies and Methods Drug Discovery Strategies and Methods
Drug Discovery Strategies and Methods Drug Discovery Strategies and Methods

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